These common heterocyclic compound, 61500-87-6, name is Methyl 2-amino-4-(trifluoromethyl)benzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2-amino-4-(trifluoromethyl)benzoate
Step 2: methyl 2-(acetylamino)-4-(trifluoromethyl)benzoate To a solution of the product from Step 1 (5.34 g) in dioxane (25 ml) was added acetic anhydride (6 ml) and pyridine (4 ml). After 60 hours of stirring at 80C, the solution was concentrated under reduced pressure and the residue was dissolved into ethyl acetate. The organic layer was washed with 2M sodium carbonate, 10% aqueous HCl, water and brine, dried over sodium sulfate and evaporated. The product was purified by flash chromatography (ISCO, 5%-20% ethyl acetate in hexanes) to provide a beige solid (5.27 g). LRMS (ES+) m/z 262.0 (M+H)+.
The synthetic route of Methyl 2-amino-4-(trifluoromethyl)benzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MERCK CANADA INC.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.; RUDD, Michael, T.; MCCAULEY, John; LIVERTON, Nigel; GRISE-BARD, Christiane; BROUCHU, Marie-Christine; CHARRON, Sylvie; AULAKH, Virender; BACHAND, Benoit; BEAULIEU, Patrick; ZAGHDANE, Helmi; HAN, Yongxin; FERRARA, Marco; HARPER, Steven; SUMMA, Vincenzo; CHACKALAMANNIL, Samuel; VENKATRAMAN, Srikanth; SHAH, Unmesh; VELAZQUEZ, Francisco; WO2013/74386; (2013); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics