90942-47-5, name is Methyl 5-(aminomethyl)-2-chlorobenzoate hydrochloride, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: esters-buliding-blocks
To a solution of methyl 5-(aminomethyl)-2-chlorobenzoate hydrochloride (2.50 g,10.59 mmol) in THF (20 mL) were added DIPEA (4.78 g, 37.07 mmol) andisobutyryl chloride (1.70 g, 15.89 mmol). The reaction mass was stirred at RT for 2 h. After completion of the reaction, the reaction mixture was diluted with EtOAc, washed with water and brine, dried over Na2 SO4 and concentrated to afford 1.2 g of the desired product. ?H NIVIR (300 IVIHz, DMSO-d6): 8.35 (t, 1H), 7.66 (s, 1H),7.55-7.52 (d, J= 8.1 Hz, 1H), 7.43-7.40 (d, J 8.1 Hz, 1H), 4.26 (d, J 5.7 Hz, 2H),3.85 (s, 3H), 2.44 (m, 1H), 1.02 (d, J= 6.9 Hz, 6H); MS [M+H]: 270.12.
The synthetic route of 90942-47-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; TAMBE, Macchindra Sopan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2015/59618; (2015); A1;,
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