Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-bromo-4-methylbenzoate
[0202] A mixture of the above product (0.600 g, 1.57 mmol), methyl 2-bromo-4-methylbenzoate (0.395 g, 1.72 mmol), potassium carbonate (0.541 g, 3.92 mmol), triphenylphosphine (0.016 g, 0.06 mmol), and palladium acetate (3.5 mg, 0.01 mmol) in 7 mL of THF and 0.2 mL of water was heated in a sealed flask at 100 C. overnight. The mixture was then cooled and partitioned between ethyl acetate and water. The organic extract was washed with brine, dried over Na2SO4, filtered and concentrated under vacuum. The residue was subjected to silica gel chromatography eluted with 0-10% ethyl acetate and hexane to provide methyl 5-methyl-4′-{(1R)-1-[(4-methyl-3-nitropyridin-2-yl)amino]ethyl}-1,1′-biphenyl-2-carboxylate that gave a proton NMR spectrum consistent with theory and a mass ion (ES+) of 406.2 for M+H+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Wai, Jenny Miu-Chun; US2004/34064; (2004); A1;,
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