Reference of 57625-74-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Into a 250-ML THREE-NECKED FLASK there were placed 2.5 g of 2-PHENYL-2-METHYL propionic acid methyl ester and 2.4 g of zinc cyanide and 100 ml of tetrachloroethane. A strong flow of hydrogen chloride was introduced into the flask with intense stirring during 4 hours. The flask was cooled down with an ice bath and 4.8 g of finely divided aluminium chloride were added in one dose with continued intense stirring. The stirring continued for another thirty minutes and the flask was placed onto an oil bath where it was gradually heated up to the temperature of 70 C. Further on, the mixture was kept at the given temperature for three hours. After cooling with running water, the contents of the flask were poured onto crushed ICE/15M1 conc. HCI. The reaction mixture was left to stand overnight. Then it was transferred to the flask where it was REFLUXED for three hours and after cooling, it was divided in a separatory funnel. The organic layer was separated; the aqueous layer was extracted with 15 mi of TETRACHLOROETHANE. The combined organic extracts were washed with water, with 10% sodium carbonate and dried over sodium sulphate. The solvent was distilled off until 1/3 of the volume and the product was filtered through a short column of silica gel. 2. 1 G of the product were obtained having 92.6% GC purity.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-2-phenylpropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ZENTIVA, A.S.; WO2004/43922; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics