Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3681-71-8, name is cis-3-Hexenyl acetate, A new synthetic method of this compound is introduced below., Safety of cis-3-Hexenyl acetate
A mixture of (Z)-hex-3 -en- 1 -yl acetate(4) 9m (0.124 g, 0.87 mmol), aminating agent la (0.208 g, 1.04 mmol), and Rh2(esp)2 (6.6 mg, 1 mol%) was stirred at rt in CF3CH2OH (8 mL). Three additional portions of catalyst (6.6 mg, 1 mol %) were added every 12 h thereafter for a total of 26.4 mg (35 //mol, 4 mol%). After a total of 51 h, the reaction mixture was quenched and chromatographically purified on a CombiFlash system using 80-100% EtOAc/hexanes as eluent to afford the title tetrahydrofuran as a viscous oil (84 mg, 61%) obtained as a mixture of diastereomers (>95:5). TLC: Rf~ 0.3 (80% EtOAc/hexanes); XH NMR (400 MHz, CDC13) (major diastereomer) delta 4.23 (ddd, J= 8.7, 6.7, 4.3 Hz, 1H), 3.77-3.67 (m, 2H), 3.58-3.50 (m, 1H), 3.19 (br s, 1H), 1.92 (s, 3H), 1.87-1.68 (m, 2H), 1.63-1.37 (m, 2H), 0.90 (t, J= 7.5 Hz, 3H); 13C NMR (101 MHz, CDC13) delta 163.98, 82.16, 72.85, 58.89, 38.28, 28.28, 14.04, 9.84; HRMS (ESI+) Calcd. for [C8Hi5N02+H]+ 158.1 176, Found 158.1173; IR (neat) 3272, 2963, 2935, 1668 cm”1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ESS, Daniel, Halsell; FALCK, John, Russell; JAT, Jawahar, Lal; URTI, Laszlo; WO2015/103505; (2015); A2;,
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