Synthetic Route of 79432-87-4, A common heterocyclic compound, 79432-87-4, name is (E)-Methyl 3-(3-bromophenyl)acrylate, molecular formula is C10H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a dry flask were added (E) -methyl 3- (3-bromophenyl) acrylate (1.18 g, 4.89 mmol) , methanol (10 mL) and 10%Pd/C (120 mg) in turn, the mixture was stirred at 40 under H2for 6 hours. The mixture was filtered and the filtrate was concentrated in a rotary evaporator to get the title compound as a brown liquid (1.2 g, 100%) . ESI: (ESI, pos. ion) m/z: 243.1 [M+H]+.
The synthetic route of 79432-87-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Xinchang; REN, Qingyun; YAN, Guanghua; GOLDMANN, Siegfried; ZHANG, Yingjun; (253 pag.)WO2019/76310; (2019); A1;,
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