Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate, A new synthetic method of this compound is introduced below., Formula: C10H8Br2O4
210 mg of 4-fluorothiopheneboronic acid, 170 mg of dimethyl 2,5-dibromobenzene-1,4-dicarboxylate,116mg PdCl2 (MeCN) 2, 336mg saturated K2CO3 aqueous solution was placed in a two-port bottle,Add 12 mL of tetrahydrofuran,The mixture was heated and stirred under reflux for 7 hours under argon.After cooling to room temperature, it was extracted with 30 mL of diethyl ether.The combined organic layers were washed with saturated brine andNa2SO4 is dry.The solution was then filtered and the solvent removed to give a crude material which was crystallised from ethanol.The product was obtained as a yellow solid. A mixture of 500 mg of yellow solid in 20 mL of ethanol and 286 mg of NaOH was refluxed for 7 h.After cooling to room temperature, the mixture was poured into hydrochloric acid.A yellow solid product was obtained by suction filtration.The yellow solid was mixed with 50 mL of polyphosphoric acid, and the mixture was stirred at 130 C for 3 hours and then washed with ice water. A black solid crude product was obtained by suction filtration.The obtained crude product was recrystallized from dimethylformamide to give a final product with a metallic luster.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Lanzhou University; Zhang Haoli; Liu Duanwu; Lin Zewei; Xu Zhuguo; Shi Zifa; (13 pag.)CN109678877; (2019); A;,
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