Some common heterocyclic compound, 16519-02-1, name is Diethyl 2-fluoro-2-methylmalonate, molecular formula is C8H13FO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H13FO4
Diethyl 2-fluoro-2- methylmalonate (1 eq.) from the previous step was taken up in an aqueous pH=7.3 phosphate buffer (0.14 M, prepared by dissolving 7.3 g of NaHP04 and 2.1 g of KH2P04 per L of water). Lipase from Candida Rugosa (70 mg per mmol of substrate, 847 U/mg, Sigma Cat L1754) was then added and the resulting heterogeneous mixture was vigorously stirred at RT for 18 h. Depending on scale, occasional addition of 1 N NaOH was necessary to maintain the pH of the reaction mixture at -7.3 to ensure optimal activity. The reaction mixture was then added celite, stirred at RT for 1 h and filtered. The filtrate was extracted with EtOAc, dried over MgS04, and filtered. Concentration of the filtrate in vacuo furnished the desired product as a white, crystalline solid (71% yield, 93% enantiomeric excess).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16519-02-1, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; LAN, Ruoxi; CHEN, Austin; CLARK, Ryan C.; (125 pag.)WO2017/49069; (2017); A1;,
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