Adding a certain compound to certain chemical reactions, such as: 1732-08-7, name is Dimethyl pimelate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1732-08-7, Application In Synthesis of Dimethyl pimelate
Dimethyl pimelate (3.76 g, 20 mmol) was added dropwise to a suspension of NaH(1.06g, 26.6 mmol, 60% in mineral oil) in dry THF (20 mL). The resulting slurry wasstirred at RT overnight. The reaction was quenched with water (5 mL), extracted withEtOAc (20 mL× 3), washed with brine, dried (Na2SO4), and concentrated undervaccum. The residue was chromatographed with petrolum ether-EtOAc (20:1) to give the desired methyl 2-cyclohexanonecarboxylate as a colorless oil. (2.42 g, 77%).
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Reference:
Article; Qian, Hua; Gu, Guoxian; Zhou, Qinghai; Lu, Jiaxiang; Chung, Lung Wa; Zhang, Xumu; Synlett; vol. 29; 1; (2018); p. 51 – 56;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics