Reference of 25415-67-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25415-67-2, name is Ethyl 4-methylpentanoate, This compound has unique chemical properties. The synthetic route is as follows.
Tetrahydrofuran (35 ml) was cooled down to -70C under inert gas atmosphere. At this temperature, 4.44 ml (11.1 mmol) of n-butyllithium solution (2.5 M in hexanes) and then 0.51 ml (9.71 mmol) acetonitrile were added dropwise. After 3 min at -70C, 1 .1 5 ml (6.93 mmol) ethyl 4- methylpentanoate were added dropwise at such a rate that the temperature of the solution did not exceed -66C. The mixture was stirred for 2 h at -45C before 22.2 ml of 1 N hydrochloric acid were added dropwise. The reaction mixture was concentrated under reduced pressure, and the residue was mixed with diethyl ether. After filtration through silica gel, the filtrate was evaporated under reduced pressure to yield 1.05 g of the crude title compound, which was used in the next step without further purification.GC-MS (method 5): Rt = 3.23 min; MS (EIpos): m/z = 138 (M-H)+ ‘H-NMR (DMSO-dg): delta = 4.03 (s, 2H), 2.51 (t, 2H), 1.50 (sext, 1H), 1.38 (q, 2H), 1.35 (d, 6H) ppm.
The chemical industry reduces the impact on the environment during synthesis Ethyl 4-methylpentanoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Bayer Schering Pharma AG; MICHELS, Martin; FOLLMANN, Markus; VAKALOPOULOS, Alexandros; ZIMMERMANN, Katja; TEUSCH, Nicole; LOBELL, Mario; ENGEL, Karen; WO2011/42367; (2011); A1;,
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