Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41727-48-4, name is Methyl 4-amino-3,5-dichlorobenzoate, A new synthetic method of this compound is introduced below., Safety of Methyl 4-amino-3,5-dichlorobenzoate
Example 45 Preparation of methyl 3,5-dichloro-4-cyanobenzoate (C77) Copper(I) cyanide (7.41 g, 82.7 mmol) was added to acetonitrile and heated to 80 C. for 30 minutes. tert-Butyl nitrite (10.5 g, 102 mmol) was added followed by methyl 4-amino-3,5-dichloro-benzoate (14.0 g, 63.6 mmol) in acetonitrile (200 mL) and the reaction mixture was stirred at 80 C. for 30 minutes. The reaction mixture was poured into an ammonia solution and extracted with petroleum ether to provide the title compound as an off-white solid (7.00 g, 43%): mp 98-101 C.; 1H NMR (400 MHz, CDCl3) delta 8.12 (s, 2H), 3.98 (s, 3H); ESIMS m/z 229 ([M+H]+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Dow AgroSciences LLC; LePlae, JR., Paul R.; Barton, Thomas; Gao, Xin; Hunter, Jim; Lo, William C.; Boruwa, Joshodeep; Tangirala, Raghuram; Watson, Gerald B.; Herbert, John; (147 pag.)US2017/210723; (2017); A1;,
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