Application of 871224-19-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 871224-19-0, name is Methyl 3-bromo-2-chlorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of methyl 3-bromo-2-chlorobenzoate (2.3 g, 9.27 mmol) in 1,4-dioxane (20 mL) at room temperature were added (Bpin)2 (3.5 g, 13.91 mmol), KOAc (2.7 g, 27.8 mmol) and Pd2(dppf).CH2Cl2 (0.34 g, 0.46 mmol) and degassed with argon for 5 min. The resulting mixture was maintained at 100 C. for 16 h. The reaction mixture was filtered through celite pad and the filtrate was concentrated under reduced pressure to get methyl 2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (5 g crude compound) as a dark brown semi-solid. The crude product was used for the next step without purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-2-chlorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Polaris Pharmaceuticals, Inc.; WEBBER, Stephen E.; ALMASSY, Robert J.; (75 pag.)US2018/65917; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics