In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89901-03-1 as follows. SDS of cas: 89901-03-1
Example 97; (4′ -Bromo-biphenyl-4-yl) -methanol; A solution of 4′ -Bromo-biphenyl-4-carboxylic acid methyl ester, 7.8g (27.9′ mmol) in 15OmL of tetrahydrofuran was cooled to 0 0C via ice-water bath. Lithium aluminum hydride, l.lg (27.9 mmol) was added to the solution in one portion. The reaction mixture stirred at 0 0C for Ih. The mixture was slowly quenched with 1OmL of isopropyl alcohol, then with 1OmL of water. The aqueous mixture was extracted with 3x50mL portions of ethyl acetate. The organic layers were combined, washed with sat. aq. NaCl, and dried (MgSO4) . The solution was concentrated to afford the desired product in 7.01g (100%) as a white solid. The material was taken to the next step without further purification.
According to the analysis of related databases, 89901-03-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC; WO2006/55725; (2006); A2;,
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