Electric Literature of 6942-39-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6942-39-8 name is Methyl 2-bromo-5-fluorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
b)4′-Chloro-4-fluoro-3′-[[(tricyclo[3.3.1.13’7]dec-l-ylmethyl)amino]carbonyl]-[l,l’-biphenyI]-2-carboxylic acid, methyl ester[4-Chloro-3-[[(tricyclo[3.3.1.13>7]dec-l-ylmethyl)amino]carbonyl]phenyl]-boronic acid(Example 2 (a)) (200 mg), 2-bromo-5-fluoro-benzoic acid, methyl ester (Example 51 (a))(170 mg), tetrahydrofuran (2 mL), a solution of potassium carbonate (166 mg) in water (1mL) and fe(triphenylphosphine)palladium(II) chloride (20 mg) were placed in a 10 mLmicrowave vial. The mixture was heated to 70 C for 1 hour in a microwave thenevaporated. The residue was partitioned between dichloromethane (20 mL) and water (20mL). The layers were separated and the aqueous was extracted with dichloromethane(2×20 mL). The combined organics were dried (MgSCU,), filtered and evaporated.Purification by chromatography (SiOa, 1:4 ethyl acetate :isohexane as eluant) gave the sub- title compound as an oil (79 mg).MS: APCI(+ve) 456/458 (M+H+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-bromo-5-fluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; WO2006/25783; (2006); A1;,
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