Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41727-48-4, name is Methyl 4-amino-3,5-dichlorobenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C8H7Cl2NO2
(i) Sodium nitrite (20 g) in water (50 ml) was added to a stirred mixture of methyl 4-amino-3,5-dichlorobenzoate (6.23 g) in concentrated sulphuric acid (110 g) and water (95 ml) at 0C. The mixture was stirred until all the solid had dissolved (overnight at 0C). To the stirred solution was added a solution of potassium iodide (25 g) in water at 50C and the resulting mixture was stirred at 20C overnight. The mixture was extracted with diethyl ether. The ethereal extracts were washed with aqueous sodium bisulphite solution and then dried over anhydrous magnesium sulphate. The solvent was evaporated in vacuo and the residue was chromatographed on silica, eluding with hexane: dichloromethane 7:3. 3.75 g of methyl 3,5-dichloro-4-iodobenzoate was obtained. Nuclear magnetic resonance spectrum (NMR) was as follows: ‘H (ppm from TMS in CDCl3, integral, number of peaks): 3.90, 3H, s; 7.95, 2H, s. Mass spectrum M+1 331.
The synthetic route of 41727-48-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE WELLCOME FOUNDATION LIMITED; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; EP279698; (1990); A3;,
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