Application of 18014-00-1, These common heterocyclic compound, 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
210 mg of 4-chlorothiophene boric acid,151 mg of dimethyl 2,5-dibromobenzene-1,4-dicarboxylate,116mg PdCl2(PPh3)2, 434.7mg saturated K2CO3 aqueous solution was placed in a two-port bottle,Add 12 mL of tetrahydrofuran,The mixture was heated and stirred under reflux for 9 hours under argon.After cooling to room temperature, it was extracted with 30 mL of ethyl acetate.The combined organic layers were washed with saturated brine andNa2SO4 is dry.The solution was then filtered and the solvent removed to give a crude material which was crystallised from ethanol.The product was obtained as a yellow solid.
Statistics shows that Dimethyl 2,5-dibromoterephthalate is playing an increasingly important role. we look forward to future research findings about 18014-00-1.
Reference:
Patent; Lanzhou University; Zhang Haoli; Liu Duanwu; Lin Zewei; Xu Zhuguo; Shi Zifa; (13 pag.)CN109678877; (2019); A;,
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