Adding a certain compound to certain chemical reactions, such as: 651734-58-6, name is Methyl 2-fluoro-3,5-dimethoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 651734-58-6, COA of Formula: C10H11FO4
S02C12 (4.13g, 30.84 mmol) was added dropwise to a solution of methyl 2-fluoro-3,5-dimethoxy benzoate (6g, 28.03 mmol) in acetonitrile (lOOmL) at 0 C under nitrogen atmosphere. The resulting reaction mixture was wanned to room temperature slowly and stined for lh. The reaction mixture was quenched with saturated sodium bicarbonate solution, and extracted with ethyl acetate (3x30mL). The organic phase was washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified by triturating with 30% ether-pentane to afford the desired title compound (5g, 71%) as a solid. ‘HNMR (CDCI3, 400MHz): delta 6.63 (d, 1H), 3.96 (s, 3H), 3.9 (d, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-fluoro-3,5-dimethoxybenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sudeep; SATOH, Takashi; SELVARAJ, Anand; (96 pag.)WO2016/164754; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics