Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 24812-89-3
To a solution of 6-chloro-3-methyl-pyridine-2-carboxylic acid (0.8 g, 4.6 mmol) in CH2CI2 (4 mL) at room temperature are added methyl 3-amino-2,4- dimethyl-benzoate (0.84 g, 4.6 mmol) and TEA (945.0 mg, 9.3 mmol). After stirring 10 minutes, 1-propanephosphonic acid cyclic anhydride (50% solution in EtOAc, 2.97 g, 9.3 mmol) is added via syringe. After 2 hours at 35 C, the reaction mixture is diluted with saturated NaHC03 solution and extracted with CH2C12. The combined organic layers are dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue is purified by silica gel flash chromatography, eluting with 10% EtOAc in hexanes to give methyl 3-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-2,4-dimethyl-benzoate as a colorless oil (1.1 g, 72%). Mass spectrum (m/z): 333.3 (M+H)+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24812-89-3.
Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; MANNINEN, Peter Rudolph; SCHIFFLER, Matthew Allen; VETMAN, Tatiana Natali; WARSHAWSKY, Alan M.; YORK, Jeremy Schulenburg; WO2015/94912; (2015); A1;,
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