Related Products of 18013-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18013-97-3, name is Diethyl 2,5-dibromoterephthalate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2,5-Dibromo-terephthalic acid diethyl ester (20 g, 53 mmol), dibenzofuran- 1 -boronic acid (29 g, 137 mmol) and tripotassiumphosphate monohydrate (48.5 g, 160 mmol) were added to water/toluene/dioxane (1 :1 :1 , 0.5 L). The solution was saturated with argon. Palladium(ll)-acetate (1 18 mg, 0.5 mmol) and tri-o-tolyl-phosphine (480 mg, 1 .6 mmol) were added and the reaction mixture was refluxed for 16 hours. After cooling down to room temperature, toluene (500 mL) was added and the organic phase was washed with water (3 x 500 mL) and then concentrated under reduced pressure. The residue was purified by recrystallization from toluene/ethanol. Yield: 22.2 g (40 mol; 76 %).
The synthetic route of Diethyl 2,5-dibromoterephthalate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; LINGE, Rouven; RODRIGUEZ, Lara-Isabel; MEYER, Sebastian; HEIL, Holger; (112 pag.)WO2018/95888; (2018); A1;,
Ester – Wikipedia,
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