In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 711-01-3, name is Methyl adamantane-1-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl adamantane-1-carboxylate
To 97 g (499 mmol) of methyl 1-adamantanecarboxylate obtained in Preparation Example 1, 485 g of toluene was added, and nitrogen substitution was carried out, followed by cooling with a refrigerant.While maintaining the toluene solution at 10 ¡ã C. or less, 270 mL (540 mmol) of a solution of methylmagnesium chloride in tetrahydrofuran (THF) (2 M) is added dropwiseThereafter, the temperature was raised naturally, and reaction was performed at room temperature (25 ¡ã C.) for 3 hours.The reaction solution was cooled again with a refrigerant, and 179 g (1160 mmol) of methacrylic anhydride was added dropwise while maintaining the temperature at 10 ¡ã C. or less.Thereafter, the temperature was raised naturally, and reaction was performed at room temperature (25 ¡ã C.) for 3 hours.The crude reaction solution was washed with a 2N aqueous hydrochloric acid solution while keeping the temperature at 25 ¡ã C. or lower, and the aqueous layer was separated.Subsequently, the organic layer obtained is washed with a 10percent aqueous sodium hydroxide solution and saturated brine, and the solvent is evaporated under reduced pressure,Crude 1- (1-adamantyl) -1-methylethyl methacrylate was obtained.(Yield 129.9 g, GC purity 82.3percent)
The synthetic route of 711-01-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Osaka Organic Chemical Industry Ltd.; Kojima, Akio; Kono, Naoya; Uenoyama, Yoshitaka; (20 pag.)JP6478447; (2019); B2;,
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