Adding a certain compound to certain chemical reactions, such as: 252881-74-6, name is tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 252881-74-6, Product Details of 252881-74-6
Example 32Step 1: ( 15R,19R)-tert-butyl 15-(((( 9H-fluoren-9-yl)methoxy)carbonyl)amino)-19-( dodecyloxy)-14- oxo-4, 7, 10,21 -tetraoxa-17-thia-13-azatritriacontan-l-oate[000538] To a solution of (?)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(((?)-2,3- bis(dodecyloxy)propyl)thio)propanoic acid (1 eq, from example 20, step 5) and HBTU (1.2 eq) inDCM (0.06 M) was added DIEA (3.5 eq), followed by teri-butyl 3-(2-(2-(2- aminoethoxy)ethoxy)ethoxy)propanoate (1.2 eq). The reaction was stirred at room temperature for2 hours. The crude mixture was purified by flash chromatography on a COMBIFLASH system(ISCO) using 0-5% MeOH/DCM to give the title product as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate, and friends who are interested can also refer to it.
Reference:
Patent; IRM LLC; WU, Tom Yao-Hsiang; ZOU, Yefen; HOFFMAN, Timothy Z.; PAN, Jianfeng; WO2011/119759; (2011); A1;,
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