Related Products of 18595-12-5, A common heterocyclic compound, 18595-12-5, name is Methyl 5-amino-2-methylbenzoate, molecular formula is C9H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 82; Preparation of inhibitor methyl 5-(5-(4-((4~methyipiperazin-1-yl)methyl)- benzamido)-2-methylbenzamido- 1 H-pyrro/o/2, 3-b]pyridine-2-carboxylate (ND0117); Step 1 : Preparation of methyl5-(4-(chloromethyl)benzamido)-2-methylbenzoate; A reactor is charged with 1g (6.06 mmol) of methyl 3-amino-6-methylbenzoate and 1.2g (119 mmol) of triethylamine in 25 ml of dichloromethane. 1.145g (6.05 mmol) of 4-chioromethylbenzoyle chloride is then added and the mixture is stirred at room temperature for 2 hours. The reacting medium is then washed with 10 ml of a saturated NaHCO3 solution, 10 ml of water and 10 ml of a saturated NaCI solution. The organic phase is dried, evaporated and the obtained residue is triturated in ethylic ether and then in pentane to give a white solid (1.2 g, 66%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NOVA DECISION; AZASYNTH; YASRI, Abdelaziz; CHEVE, Gwenael; BORIES, Cedric; DELON, Louis; WO2010/92489; (2010); A1;,
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