Extracurricular laboratory: Synthetic route of Methyl 2-bromobutyrate

The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.

3196-15-4, name is Methyl 2-bromobutyrate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 3196-15-4

General procedure: As part of this general procedure, the appropriate diphenyl diselenide (9.5 mmol) dissolved in a 1:1 mixture of water and THF (50 mL) underprotective nitrogen gas, sodiumborohydride (47.5 mmol) was added and the mixture was stirred for around 35 minutes while observing adecolorization in the first 1-3 minutes. Next, a solution of a methyl -2-bromo-acetate derivatives (19.37 mmol) in THF or DCM (5 mL) wasadded and the reaction was stirred at room temperature and monitored via thin layer chromatography (TLC). Upon consumption of the startingmaterial usually occuring after 24-48 hours, the reaction mixture was diluted with 50 mL of a saturated aqueous solution of ammoniumchloride and extracted with diethyl ether. The combined organic extracts dried over sodium sulfate, and the solvent was evaporated under reducedpressure to obtain the desired intermediate, which was used without further purification.

The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ali, Wesam; Battistelli, Cecilia; D?browska, Monika; Handzlik, Jadwiga; Honkisz-Orzechowska, Ewelina; Jacob, Claus; Kincses, Annamaria; Latacz, Gniewomir; Nove, Marta; Rasile, Manuela Monica; Romanelli, Annalisa; Spengler, Gabriella; Starek, Ma?gorzata; Szyma?ska, Ewa; Zwergel, Clemens; European Journal of Medicinal Chemistry; vol. 200; (2020);,
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