Synthetic Route of 91-44-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 91-44-1 as follows.
To a 50 mL round bottom flask containing acetonitrile (20 mL) was added 7-(diethylamino)-4-methylcoumarin (1.01 g, 4.37 mmol). Then N-bromosuccinimide (0.86 g, 4.8 mmol) was added in portions. After stirring at room temperature for 23 h, the reaction mixture was poured into water after the reaction was completed. The organic phase was extracted three times with ethyl acetate and dried over anhydrous sodium sulfate. The solvent was removed by evaporation to give a yellow powder.
According to the analysis of related databases, 91-44-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sun Yat-sen University; Song Huacan; Cao Wenyan; Song Senchuan; Liu Jiarong; (18 pag.)CN109574942; (2019); A;,
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