Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 251458-15-8, name is Methyl 2-(3-bromophenyl)-2-methylpropanoate, A new synthetic method of this compound is introduced below., COA of Formula: C11H13BrO2
To a solution of ester from step 1 in THF-MeOH (4: 1,0. 5M) was added LIOH (3 eq, 2M) and the mixture was stirred at 50C for 1h. The organic solvent evaporated, aqueous was acidified with HCl IN and the acid extracted with EtOAc (3X). The organic was washed with brine, dried and solvent evaporated to afford the acid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK FROSST CANADA & CO.; WO2004/48374; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics