Adding a certain compound to certain chemical reactions, such as: 17100-65-1, name is Methyl 2-bromo-4-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17100-65-1, HPLC of Formula: C9H9BrO3
A mixture of methyl 2-bromo-4- methoxybenzoate (4) (5.9 g, 23.9 mmol), butyl vinyl ether (15.4 mL, 119.4 mmol), Ph3P (939.0 mg, 3.6 mmol), Et3N (4.3 mL, 31.0 mmol), and Pd(OAc)2 (343.0 mg, 1.8 mmol) in MeCN (45 mL) is stirred under argon at 97 C for 18 h, cooled to room temperature, diluted with H2O (50 mL), and filtered through Celite (H2O rinse). The filtrate is concentrated to dryness at reduced pressure. The residue plus tetrahydrofuran (140 mL) and 10% HCl (140 mL) were stirred for 2 h. After tetrahydrofuran removal at reduced pressure, the residue is extracted with dichloromethane (3 x 70 mL). The extract is washed (brine) and dried. After solvent removal at reduced pressure, the residue is purified on silica gel (16.7% to 33.3% ethyl acetate/hexane) to give 4.8 g (96%) of 5 as a yellow solid, mp 48-50 C. IR 2962, 1733, 1688, 1258 cm”1; 1HNMR (CDCl3) delta 2.50 (s, 3H, CH3CO), 3.86 (s, 6H, CH3O, CO2CH3), 6.76 (d, J= 2.0 Hz, IH, 3-PhH), 6.93 (dd, J= 7.2, 2.0 Hz, IH, 5-PhH), 7.90 ppm (d, J= 7.2 Hz, IH, 6-PhH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-4-methoxybenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BURNHAM INSTITUTE FOR MEDICAL RESEARCH; MERCOLA, Mark; DAWSON, Marcia, I.; CASHMAN, John; WO2010/33643; (2010); A2;,
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