Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42726-73-8, name is tert-Butyl methyl malonate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 42726-73-8
Sodium hydride (15.6 g) was suspended in 300 mL of tetrahydrofuran under a nitrogen stream, and Compound1 (30 mL) was added dropwise over 30 minutes under ice cooling. After the mixture was stirred under ice cooling for 30minutes, methyl iodide (24.3 mL) was added dropwise, and the mixture was stirred at room temperature for 16 hours.To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The extract was washedwith saturated brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reducedpressure to obtain Compound 2 (24.76 g). The obtained Compound 2 (24.76 g) was dissolved in tetrahydrofuran (320mL), 1M lithium hydroxide tri-tert-butoxyaluminum (300 mL) was added dropwise over 45 minutes under a nitrogenstream at room temperature, and the mixture was heated at reflux for 2 hours. To the reaction solution was addedsaturated brine, and the mixture was filtered through Celite and washed with ethyl acetate. The filtrate was concentratedunder reduced pressure, to the concentrated residue were added ethyl acetate and water, and the mixture was extractedwith ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. Afterthe solution was concentrated under reduced pressure, the obtained residue was distilled under reduced pressure toobtain Compound 3 (13.52 g).MS (m/z): 175 [M+H]+
According to the analysis of related databases, 42726-73-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; SARUTA, Kunio; HAYASHI, Norimitsu; SAKURAI, Osamu; SAWAMOTO, Hiroaki; OBOKI, Eri; EP2862856; (2015); A1;,
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