Adding a certain compound to certain chemical reactions, such as: 105-53-3, name is Diethyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 105-53-3, Application In Synthesis of Diethyl malonate
EXAMPLE 1 Preparation of ethyl 2-ethoxycarbonyl-4-methylvalerate Diethyl malonate (20 g; 124.8 mmoles) was added to a mixture of metallic sodium (2.87 g; 124.8 mmoles) dissolved in absolute ethanol (60 ml) at 50 C. After 1 hour at room temperature isobutyl bromide 97% (16.78 g; 118.8 mmoles) was added dropwise. After 2.5 hours at reflux temperature, the reaction mixture was kept at room temperature overnight. After adding hydrochloric acid 1N up to pH 4-5, ethanol was evaporated and the residue was extracted with ethyl ether. After drying and evaporating the solvent at reduced pressure, the crude oil was purified by distillation at 78 C./2.5 mmHg after the removal of the exceeding diethyl malonate at 65 C./7 mmHg. Ethyl 2-ethoxycarbonyl-4-methylvalerate (14.4 g; 56% yield) was obtained as a colorless oil. 1 H-NMR (200 MHz, CDCl3): delta (ppm): 0.87 (d, 6H); 1.21 (t, 6H); 1.52 (m, 1H); 1.75 (t, 2H); 3.47 (t, 1H); 4.15 (q, 4H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl malonate, and friends who are interested can also refer to it.
Reference:
Patent; Zambon Group S.p.A.; US5739123; (1998); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics