In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25662-28-6 as follows. name: Methyl 1-cyclopentene-1-carboxylate
Example 1: Synthesis of compound of formula (IX) A solution of methyl- 1-cyclopentene-l -carboxylate (X) (10 mL, 81.88 mmol) in CH2C12 (200 mL) under N2 atmosphere is brought to 0C, and a solution of 1M DIBALH (diisobutylaluminium hydride) in hexane (204.7 mL, 204.7 mmol) is added drop by drop. The mixture is kept under stirring a 0C for 1 hour. H2O is added to the reaction, insolubles are filtered through celite, and the phases are separated. The organic phase is washed with brine, dried over Na2SO4, filtered and evaporated under low pressure. The pure compound of formula (IX) is obtained. Yield: 95% (7.62 g of a colourless liquid). Rf: 0.28 (EtPet/EtOAc 9: 1). ^- MR 400 MHz (CDC13) delta (ppm): 5.56 (s, 1H); 4.13 (s, 2H); 2.76 (bs, 1H); 2.30-2.26 (m, 4H); 1.90-1.82 (m, 2H). 13C-NMR 100 MHz (CDC13) delta (ppm): 143.67; 125.06; 61.60; 32.08; 31.86; 22.97. MS(ES+): m/z 121 [M+Na]+.
According to the analysis of related databases, 25662-28-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DIPHARMA FRANCIS S.R.L.; TADDEI, Murizio; ATTOLINO, Emanuele; BALDUCCI, Evita; MICHIELETTI, Mario; WO2013/120871; (2013); A1;,
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