Some common heterocyclic compound, 625-56-9, name is Chloromethyl acetate, molecular formula is C3H5ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Chloromethyl acetate
Reference Example 15 A mixture of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-imidazolidinone (0.30 g) and chloromethyl acetate (1.35 g) was stirred for 24 hours at 100 C. The reaction mixture was concentrated under reduced pressure. The residue was subjected to ODS column chromatography (eluent: methanol/water=3/2) to give 4-acetoxymethyl-1-[(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxy-3-[2-oxo-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-1-imidazolidinyl]butyl]-1H-1,2,4-triazolium chloride (Compound 3, 45 mg) as a white powder. 1H-NMR(d6-DSMO) delta: 0.97(3H,d,J=7 Hz), 2.08(3H,s), 3.61-4.08(4H,m), 4.65-4.75(1H,m), 4.86(1H,d,J=14 Hz), 5.11(1H,d,J=14 Hz), 6.07-6.20(2H,m), 6.69(1H,s), 6.96-7.05(1H,m), 7.25-7.36(2H,m), 7.82-7.95(5H,m), 8.78(1H,s), 9.06(1H,s), 10.46(1H,s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 625-56-9, its application will become more common.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US6583164; (2003); B1;,
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