Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14064-10-9, name is Diethyl 2-chloromalonate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H11ClO4
REFERENCE EXAMPLE 5a Ethyl 3-amino-4-cyclopropylfuran-2-carboxylate; To a solution of compound obtained in reference example 4a (5 g, 43.47 mmol) in DMF (108 ml_) was added diethyl chloromalonate (8.4 ml_, 52.17 mmol). The reaction mixture was stirred overnight at room temperature. After diluting with water (500 ml_), the reaction mixture was extracted with ethyl acetate. The combined organic extracts were dried over Na2SO4. After filtration, the filtrate was concentrated to dryness providing an orange syrup. The orange syrup was dissolved in ethanol (217 ml_) to which 1 ,5-diazabicyclo[4.3.0]non-5-ene (5.9 ml_, 47.8 mmol) was added, and the mixture was stirred at room temperature overnight. The solution was concentrated to dryness and the crude residue was purified by flash chromatography on silica gel using ethyl acetate and hexane mixtures of increasing polarity to afford 3 g of the title compound (yield: 65percent) as a light brown oil. LC-MS (Method 2): tR = 1.88 min; m/z 196 (MH+).
According to the analysis of related databases, 14064-10-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PALAU PHARMA, S. A.; WO2009/115496; (2009); A1;,
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