6520-83-8, name is Ethyl 2-methoxy-6-methylbenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Ethyl 2-methoxy-6-methylbenzoate
Ethyl 3-bromo-6-methoxy-2-methylbenzoate (13-2). To a methylene chloride solution (100 mL) of Ethyl 2-methoxy-6-mefhylbenzoate (13-1, 5 g, 25.8 mmol, TCI Ml 120) was added bromine (1.65 mL, 32.2 mmol, 1.25 equiv) at O 0C. The reaction was stirred at O 0C to 25 0C for 12 h and quenched with sodium thiosulfate solution (5%, 20 mL) and stirred for 20 min. The resulting mixture was extracted with methylene chloride. The combined methylene chloride extracts were dried(Na2SO4) and concentrated to give 7.2 g of 13-2: 1H NMR (400 MHz, CDCl3) delta 7.47 (d, J= 9.2 Hz, 1 H), 6.63 (d, J= 9.2 Hz, 1 H)5 4.38 (q, J= 7.3 Hz, 2 H), 3.78 (s, 3 H), 2.30 (s, 3 H), 1.35 (, J= 7.3 Hz, 3 H).
The synthetic route of 6520-83-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TETRAPHASE PHARMACEUTICALS, INC.; DENG, Yonghong; PLAMONDON, Louis; SUN, Cuixiang; XIAO, Xiao-Yi; ZHOU, Jingye; SUTCLIFFE, Joyce, A.; RONN, Magnus, P.; WO2011/25982; (2011); A2;,
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