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Controllable Lewis Base Catalyzed Michael Addition of alpha-Aminonitriles to Activated Alkenes: Facile Synthesis of Functionalized gamma-Amino Acid Esters and gamma-Lactams
A novel protocol for the synthesis of functionalized gamma-amino acid esters and gamma-lactams through a controllable Lewis base catalyzed Michael addition of alpha-aminonitriles to simple activated alkenes has been developed. The scope, versatility, and efficiency of the process were demonstrated.
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