One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 23426-63-3, Name is Methyl 2-bromo-2-methylpropanoate, formurla is C5H9BrO2. In a document, author is Yang, Dan, introducing its new discovery. Recommanded Product: Methyl 2-bromo-2-methylpropanoate.
Antioxidant and alpha-Glucosidase Inhibitory Activities Guided Isolation and Identification of Components from Mango Seed Kernel
In the present study, petroleum ether, dichloromethane, ethyl acetate, and n-butanol fractions of mango seed kernel exhibited different degrees of antioxidant and alpha-glucosidase inhibitory activity. Thus, quantitative and qualitative analysis of the petroleum ether fraction was conducted by GC-MS. Among identified components, four unsaturated fatty acids had never been reported in natural products before, together with 19 known components. In addition, 17 compounds were isolated and elucidated from other active fractions. Compounds 2, 9, 15, and 17 were isolated for the first time from Mangifera genus. Compounds 1 and 2 exhibited prominent DPPH radical scavenging and alpha-glucosidase inhibitory effects. In order to further explore their mechanism of alpha-glucosidase inhibition, their enzyme kinetics and in silico modeling experiments were performed. The results indicated that 1 inhibited alpha-glucosidase in a noncompetitive manner, whereas 2 acted in a competitive manner. In molecular docking, the stability of binding was enhanced by pi-pi T-shaped, pi-alkyl, pi-pi stacked, hydrogen bond, and electrostatic interactions. Thus, compounds 1 and 2 were determined to be new potent antioxidant and alpha-glucosidase inhibitors for preventing food oxidation and enhancing hypoglycemic activity.
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