The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 623-47-2, 623-47-2, Name is Ethyl propiolate, SMILES is C#CC(OCC)=O, in an article , author is Yamanashi, Takehiko, once mentioned of 623-47-2.
Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of post-traumatic stress disorder (PTSD) and that anti-inflammatory drugs might be a new treatment strategy for PTSD. It has been reported that beta-hydroxybutyrate (BHB), one of the main ketone bodies produced, can have an anti-inflammatory and antidepressant effect. Here, we investigated the potential anti-anxiety and anti-inflammatory effects of BHB using a rodent PTSD model, induced by single prolonged stress (SPS). Male, Sprague-Dawley rats were employed in this study. Repeated administration of BHB attenuated SPS-induced anxiety-related behaviors evaluated by the elevated plus maze test. SPS increased the serum levels of TNF-alpha and IL-1 beta. In contrast, BHB administration partially attenuated the increase of serum TNF-alpha. These findings demonstrate that BHB exerts its anxiolytic effects, possibly by inhibiting systemic TNF-alpha. Hence, BHB may be a novel therapeutic candidate for the treatment of PTSD.
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