Application of 176694-36-3, These common heterocyclic compound, 176694-36-3, name is Methyl 4-fluoro-3-(trifluoromethyl)benzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
b N-tert-butoxycarbonyl-4-([4-methoxycarbonyl-2-methylsulfonyl)phenoxy]-phenylalanine benzyl ester 2.8 g of N-tert-butoxycarbonyl-tyrosine benzyl ester, 2.2 g of 4-fluoro-3-trifluoromethylbenzoic acid methyl ester and 4.0 g of K2 CO3 are stirred in 100 ml of DMF (anhydrous) at 110 C. for 45 minutes. The reaction mixture is poured into 500 ml of water, the pH is brought to 2 with NaHSO4 and the mixture is extracted 3 times with 200 ml of EA each time. The extract is dried over Na2 SO4 and the solvent is removed in vacuo. 4.2 g of a colorless oil. Rf (DIP)=0.12 MS (ES): 584 (M+H)+
Statistics shows that Methyl 4-fluoro-3-(trifluoromethyl)benzoate is playing an increasingly important role. we look forward to future research findings about 176694-36-3.
Reference:
Patent; Hoechst Aktiengesellschaft; US5631293; (1997); A;,
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