These common heterocyclic compound, 144267-96-9, name is Ethyl 3,4-difluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Ethyl 3,4-difluorobenzoate
Cesium carbonate (8.3 g, 25.4 mmol) was added to a mixture of 3-hydroxy-5-{[(1S)-2- hydroxy- 1 -methylethyl]o’xy) -N-( I -methyl- lH-pyrazol-3-yl)benzamide (3.7 g, 12.7 mmol) and ethyl-3,4-difluorobenzoate (2.36 g, 12.7 mmol) in dimethylacetamide (60 mL) and the stirred mixture heated at 115C for 3 hours. The mixture was allowed to cool to RT and ethyl acetate (100 mL) added. The mixture was washed with water (5 x 40 mL), brine (40 mL), dried (MgS04), filtered, and reduced in vacuo. The residue was chromatographed on silica, eluting with 50% ethyl acetate in isohexane, to give the desired compound (1.8 g). ?H NMR No. (CDC13): 1.31 (d, 3H), 1.41 (t, 3H), 3.72 (d, 2H), 3.83 (s, 3H), 4:39 (q, 2H), 4.57 (sex, 1H), 6.75 (m, 1H), 6.83 (m, 1H), 7.09 (m, 2H), 7.30 (d, 2H), 7.83 (m, 2H), 8.91 (brs, 1H). m/z 458(M+H)+
The synthetic route of Ethyl 3,4-difluorobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/121110; (2005); A1;,
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