Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4341-76-8, name is Ethyl 2-butynoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks
Step A: (Z)-methyl pent-2-enoate To a mixture of ethyl but-2-ynoate (50 g, 446 mmol) and Lindlar catalyst (9.49 g, 4.46 mmol) in 1 L round-bottom flask THF (1013 mL) and pyridine (101 mL) were added. The reaction mixture was degassed and purged with nitrogen (5*). The reaction was then blanked with a hydrogen balloon. After about 48 h the suspension was filtered through a pad of Celite washing with THF (3*100 mL). The THF was removed in vacuo at about 40 C. and 200 mbar. The residue was diluted with Et2O (1 L) and washed with water (3*200 mL) followed by 20% CuSO4 aqueous solution (5*200 mL) followed by water (3*150 mL) and dried over MgSO4, filtered and the solvent was removed in vacuo at about 40 C. and 200 mbar to give (Z)-methyl pent-2-enoate (45.3 g, 89%) as an oil. 1H NMR (400 MHz, CDCl3) delta 6.34-6.30 (m, 1H), 5.82-5.75 (m, 1H), 4.20-4.14 (m, 2H), 2.14 (dd, 3H), 1.31-1.27 (m, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ABBVIE INC.; Wishart, Neil; Bonafoux, Dominique F.; Frank, Kristine E.; Hobson, Adrian D.; Konopacki, Donald B.; Martinez, Gloria Y.; Wang, Lu; US2013/72470; (2013); A1;,
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