Application of 431-47-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 431-47-0 name is Methyl 2,2,2-trifluoroacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
e) 2,2,2-Trifluoro-N-prop-2-ynyl-acetamide To 15 g (272.3 mmol) propargylamine in 275 ml anhydrous methanol 36.6 g (285.9 mmol) methyl trifluoroacetate were added with cooling. The resulting reaction mixture was stirred for an additional four hours at room temperature. Afterwards the solvent was removed by distillation at reduced pressure. The residue was dissolved in 300 ml trichloromethane and extracted four times, twice each with 300 ml of a saturated sodium bicarbonate solution and twice each with 300 ml water. The separated organic phase was dried over magnesium sulfate, filtrated and the solvent was removed by distillation (yield: 23.3 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2,2,2-trifluoroacetate, and friends who are interested can also refer to it.
Reference:
Patent; Roche Diagnostics GmbH; F.HOFFMANN-LA ROCHE AG; EP1842923; (2007); A1;,
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