Application of 144267-96-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 144267-96-9, name is Ethyl 3,4-difluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of ethyl 3,4-difluorobenzoate (1 .5 g) in N,N-dimethylformannide (15 mL) 1 ,2,4-triazole (1 .1 g) and K2CO3 (2.3 g) are added and the mixture is heated at 150 C in a microwave for 30 min. After cooling, water and ethyl acetate are added and the organic layer is dried over MgSO4 and concentrated. The residue is purified by chromatography on silica gel eluting with 0% to 100% ethyl acetate/hexane. The pure ester is dissolved in methanol (30 mL) and 4 M aqueous NaOH solution (3 mL) is added and the mixture is stirred at room temperature for 1 h. The mixture is neutralized with 6 M hydrochloric acid, concentrated, and then acidified with 6 M hydrochloric acid, and the precipitate is filtered off washing with a small amount of water and dried by suction to give the acid as a white solid.
The chemical industry reduces the impact on the environment during synthesis Ethyl 3,4-difluorobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; NOSSE, Bernd; BLUM, Andreas; HECKEL, Armin; HIMMELSBACH, Frank; ASHWEEK, Neil J.; HARRIOTT, Nicole; WO2014/37327; (2014); A1;,
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