Synthetic Route of 3196-23-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.
AD3 (R1 and R2 together formed a cyclohexyl ring) was mixed with BocNHOH in DMSO and treated with NaH (1 equiv.) at 50 0C overnight. After aqueous work up, the crude mixture was then treated with TFA to afford AD4 (R1 and R2 together formed a cyclohexyl ring) as the TFA salt.
The chemical industry reduces the impact on the environment during synthesis Methyl 1-bromocyclohexanecarboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SCHERING CORPORATION; ZHU, Zhaoning; GREENLEE, William, J.; LI, Hongmei; VICAREL, Monica, L.; QIN, Jun; DHONDI, Pawan, Kumar; HUANG, Xianhai; PALANI, Anandan; LIU, Xiaoxiang; SUN, Zhong-Yue; JOSIEN, Hubert B.; XU, Ruo; COLE, David, James; BURNETT, Duane, A.; BENNETT, Chad, E.; MCCRACKEN, Troy, M.; MACCOSS, Malcolm; WO2010/56722; (2010); A1;,
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