Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 1-bromocyclohexanecarboxylate
General procedure: Synthesis. The mixture of zinc (3.0 g, 46 mmol), methyl 1-bromocycloalkanecarboxylate (12 mmol), HgCl2 (5 mg), and N,N-bis(arylmethylidene)benzidine 3 (5 mmol) in dry toluene(20 mL) with 2mL of HMPA was heated for 4 h under reflux and then cooled down, decanted from the zinc excess, and treated with 5% acetic acid. Organic layer was separated, and the aqueous layer was twice extracted with ethyl acetate. The combined organic layers were dried over Na2SO4 and then concentrated. The residue was purified by the recrystallization from p-xylene to give the reaction products 6a-i and 7a-k as white or Slightly colored Solids.
The synthetic route of 3196-23-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kirillov; Nikiforova; Baibarodskikh; Zakharova; Govorushkin; Journal of Chemistry; vol. 2019; (2019);,
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