Reference of 2905-67-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2905-67-1 as follows.
Step A: Preparation of 1 -(3,5 -dichlorophenyl)-3 -(2-fluorophenyl)- 1,3 -propanedioneTo a solution of tetrahydrofuran (20 mL) and sodium hydride (60% dispersion in mineral oil, 0.35 g, 8.7 mmol) was added 2?-fluoroacetophenone (0.59 mL, 4.9 mmol), followed by 3,5-dichlorobenzoic acid methyl ester (1.0 g, 4.9 mmol). The mixture was heated at reflux for 24 h. After cooling to ambient temperature, 1 N aqueous hydrochloricacid was added, and the mixture was extracted three times with dichloromethane. The extracts were combined, dried with Mg504 and filtered. The filtrate was concentrated to give a tan solid (1.8 g), which was used without further purification.
According to the analysis of related databases, 2905-67-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; SELBY, Thomas Paul; TRAVIS, David Andrew; DEPREZ, Nicholas Ryan; SATTERFIELD, Andrew Duncan; WO2015/167795; (2015); A1;,
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