Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 185629-32-7, name is Methyl 4-amino-3-fluorobenzoate, A new synthetic method of this compound is introduced below., Safety of Methyl 4-amino-3-fluorobenzoate
j00495J To a solution of methyl 4.-ainino-3-fluorohenzoate (500 mg, 3 mrnol) and DIPEA (1.65 mL, 9 mmol) in MeCN (5 mL) was added acryloyl chloride (320 mg, 16 mmoi) dropwise at 0 C. The reaction was stirred at ii for I h, then Na2CO3 aq.(sat,) was added, the resulting mixture was extracted with DCM (20 rnL x 2). The combined organic layer was concentrated and recrvstalized from EA to give YLIUi)1 164 (190 mg, 28 %) as white solid, LCMS (mz): 224 [M + H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; HAO, Mingfeng; GRAY, Nathanael, S.; ZHANG, Tinghu; KWIATKOWSKI, Nicholas, P.; (307 pag.)WO2017/44858; (2017); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics