Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 185312-82-7, name is Methyl 4-bromo-2-chlorobenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 4-bromo-2-chlorobenzoate
Step A. 2-Chloro-4-(3-dimethylaminopropyl-1-yl)-benzoic acid methyl ester Under an atmosphere of nitrogen, a mixture of 4-bromo-2-chlorobenzoic acid methyl ester (25.13 g, 101 mmol), 1-dimethylamino-2-propyne (16 mL, 150 mmol), bis(triphenylphosphine)palladium(II) chloride (1.0 g) and copper (I) iodide (0.15 g) in 100 mL of triethylamine was heated at 60 C. for 2 hours. The cooled reaction mixture was filtered through Solka floc and the cake was washed with ethyl acetate. The filtrate was partitioned between ethyl acetate and dilute aqueous sodium thiosulfate. The organic layer was washed with water, brine and dried over sodium sulfate. The dark solution was filtered through a plug of Merck-60 silica gel and the filtrate was concentrated in vacuo to give the title compound (23.8 g, 95%) as an orange oil, which was used as such in the next step. NMR (DMSO-d6, 300 MHz): delta 2.25 (s, 6H, NCH3), 3.475 (s, 2H, CCH2N), 3.84 (s, 3H, OCH3), 7.5 (dd, 1H), 7.62 (s, 1H), 7.8 (d, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; American Home Products Corporation; US6194407; (2001); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics