Electric Literature of 91-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 91-44-1 name is 7-(Diethylamino)-4-methyl-2H-chromen-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a Schlenk tube, coumarin 1 (0.5mmol), dialkyl H-phosphite 2 (1.0mmol), AgNO3 (0.025mmol, 4.2mg) and Mg(NO3)2¡¤6H2O (0.25mmol, 64mg) were added and charged with Nitrogen (3 cycles). Anhydrous CH3CN (1mL) was then added. After heating in the oil bath at 100C for 6h (monitored by TLC), 5mL ethylacetate was added to dilute the reaction solution. The solution was filtrated, and the solvent was distilled under vacuum. The crude product was purified by silica gel column chromatography to give the desired product 3 using ethylacetate/petroleum ether (1:5 to 2:1) as eluant.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Diethylamino)-4-methyl-2H-chromen-2-one, and friends who are interested can also refer to it.
Reference:
Article; Yuan, Jin-Wei; Li, Yuan-Zhe; Yang, Liang-Ru; Mai, Wen-Peng; Mao, Pu; Xiao, Yong-Mei; Qu, Ling-Bo; Tetrahedron; vol. 71; 42; (2015); p. 8178 – 8186;,
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