In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18595-14-7, name is Methyl 4-amino-3-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 18595-14-7
To a stirred and cooled (0 C) slurry of commercially available methyl 4-amino-3-methylbenzoate (2 g, 12.12 mmol) in 6 N HCl (12 mL) was added NaNO2 (0.92 g, 13.33 mmol) in water (2 mL) drop wise maintaining a temperature of <15 C during the addition. The mixture was stirred an additional 1.5 h affording a light yellow, homogeneous solution. To the mixture was carefully added 4.58 g (24.24 mmol) of anhydrous SnCl2. The temperature during the addition was kept <10 C. The mixture was stirred at 0 C for 1 h. The precipitated solid was collected by filtration, dried under vacuum to afford methyl 4-hydrazinyl-3-methylbenzoate hydrochloride 4 (1.75 g 81%) as a brown solid: mp 224-226 C; 1H NMR (CDCl3, 500 MHz) delta ppm 2.22 (s, 3H), 3.80 (s, 3H), 6.99 (d, J = 8.5 Hz, 1H), 7.70 (s, 1H), 7.77 (d, J = 8.5 Hz, 1H); MS (ESI): m/z calcd for C9H12N2O2 ([M+H]+) 181.0932; found 181.0911 ([M+H]+).
The synthetic route of 18595-14-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chiruta, Chandramouli; Zhao, Yanrong; Tang, Fangling; Wang, Tao; Schubert, David; Bioorganic and Medicinal Chemistry; vol. 21; 10; (2013); p. 2733 – 2741;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics