Reference of 623-47-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 623-47-2, name is Ethyl propiolate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of ethyl propiolate (98mg, 1.0mmol) in methanol (2mL), catalytic PtCl2 (5mg, 0.02mmol) was added. The mixture was stirred at 60C for 12h. The reaction solution was cooled to room temperature, and CH2Cl2 (20mL) was added. The mixture was then filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel with hexane-ethyl acetate (20:1) as the eluent to give a mixture of (E)-ethyl 3-methoxyacrylate (4) and ethyl 3,3-dimethoxypropanoate (5) (112mg, 85% yield, 4_5=13:1, the ratio was determined by 1H NMR) as a colorless oil.
The synthetic route of Ethyl propiolate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Qian; Zhang, Changyuan; Wen, Chunxiao; Fang, Jin; Du, Zhiyun; Wu, Dongling; Catalysis Communications; vol. 56; (2014); p. 101 – 105;,
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