Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 1150566-27-0
A heterogeneous mixture of 2-(3-fluorophenyl)piperidine (0.1 g, 0.6 mmol), spray dried potassium fluoride (0.12 g, 2.2 mmol) and ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (I-7) (0.1 g, 0.4 mmol) in DMSO (3 mL) was heated to 100 C. for 18 hours. The mixture was poured into water, extracted with EtOAc, washed with brine, dried over sodium sulfate, filtered and concentrated. The crude was purified by column chromatography on silica gel with DCM/MeOH gradient as eluant to yield ethyl 6-(2-(3-fluorophenyl)piperidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylate (X-156). 1H NMR (400 MHz, MeOD-d4) delta 8.17 (s, 1 H), 8.01 (d, J=10 Hz, 1H), 7.42-7.36 (m, 2H), 7.13-7.05 (m, 3H), 5.70 (s, 1H), 2.02-1.94 (m, 1 H), 1.79-1.70 (m, 1H), 1.63-1.57 (m, 2H), 1.47-1.37 (m, 1H), 1.29 (t, J=7.2 Hz, 3H). MS m/z 369.2 (M+1)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; IRM LLC; US2012/65184; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics