Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32122-09-1, name is Ethyl 2-(benzyloxy)acetate, A new synthetic method of this compound is introduced below., Formula: C11H14O3
To the argonated flask filled with 750 ml of dry THF cooled to -78C, 200 ml (0.5 mol) of 2.5 M n-BuLi hexane solution were added, and then 28 ml (0.533 mol) of acetonitrile were added dropwise. The whole mixture was stirred at -78C for 2 h. To the suspension 77.7 g (0.4 mol) of ethyl 2-benzyloxyacetate obtained above were added dropwise and stirring was continued at -78C for 1 h. The reaction was quenched by adding saturated ammonium chloride solution. The mixture was poured onto ice-water and acidified with 6 M hydrochloric acid. Aqueous phase was extracted with diethyl ether. Combined organic phases were washed with brine and dried over anhydrous magnesium sulphate. Drying agent was filtered off and the solvent was evaporated under reduced pressure. Intermediate XII-1 was used in the next step without purification. MS-ESI: (m/z) calculated for C11H11NO2 [M+H]+: 190.22; determined 190.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CELON PHARMA S.A.; DYMEK, Barbara; ZAGOZDA, Marcin; WIECZOREK, Maciej; DUBIEL, Krzysztof; STANCZAK, Aleksandra; ZDZALIK, Daria; GUNERKA, Pawel; SEKULAR, Mariola; DZIACHAN, Maciej; (70 pag.)WO2016/157091; (2016); A1;,
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